Greenville County EMS (GCEMS) is the sole 911/ALS provider of emergency services for Greenville County, the most populous county in South Carolina, with geographic area of almost 800 square miles of varying terrain from mountains to rural pasturelands. A dynamic high performance EMS system, GCEMS deploys up to nineteen ambulances and six Quick Response Vehicles (QRV) 24/7. Most of these ambulances are centrally deployed, while six ambulances and two QRVs are deployed from various strategic geographic locations within the county. Of the 221 field providers, 166 are certified as paramedics, 46 are certified as EMT-Intermediate and 9 as EMT-Basic. In calendar year 2011, GCEMS responded to 54,647 calls with a 90th percentile response time of 12:13 minutes for the most critical and life-threatening (Delta and Echo) calls.

GCEMS also operates an accredited EMS specific Priority Medical Dispatch high performance Communications Center staffed with EMD certified personnel. Communications staff use strict medical priority dispatch algorithms to determine specific details of incidents, provide "pre-arrival" medical care instructions to the caller and dispatch appropriate medical resources. Considered a secondary PSAP, this center is responsible for all communication activities for thirteen Fire Departments, the County Coroner's Office and GCEMS. In calendar year 2011, GCEMS Communications Center processed 62,480 responses to 54,647 emergency medical calls, 7,955 fire dispatches, 691 Coroner's calls. In processing those calls, the GCEMS Communications Center handled over 157,000 telephone calls.